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Peptide Synthesis Technical Resources

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Amino acids
Allyl-protected amino-acid derivatives for Fmoc SPPS
A guide to the selection of building blocks for peptide synthesis
Optimized coupling procedures for unusual amino acids
Synthesis of peptides containing methylated lysine residues
Synthesis of peptides containing arginine residues
Resins
Practical aspects of the use of the Dbz linker in making thioesters by Fmoc SPPS
Boc-peptide resin cleavage protocols
Fmoc-peptide resin cleavage protocols
Peptide resin loading protocols
Strategies for the synthesis of peptide aldehydes
Coupling protocols
Critical evaluation of in situ coupling reagents for SPPS
Epimerization-free fragment condensation with
pseudoproline (oxazolidine) dipeptides
Optimized coupling procedures for unusual amino acids
The role of HOBt in coupling reactions
Non-explosive replacement for HOBt
Phosphopeptide synthesis
Optimized protocols for the addition of Fmoc-Aaa(PO(OBzl)OH)-OH
Phosphopeptide synthesis using Fmoc-Tyr(PO(NMe2)2-OH
Synthesis of long or difficult peptides
Application of Dmb-Dipeptides in the Fmoc SPPS of Difficult and Aspartimide-Prone Sequences
Synthesis of FBP28WW domains using pseudoproline and isoacyl dipeptides
Synthesis of β-amyloid using an isoacyl dipeptide
Synthesis of the transmembrane region of bradykinin receptor b2
Synthesis of wild-type and phosphorylated phospholamban
The synergy of ChemMatrix resin® and pseudoproline building blocks renders Rantes, a complex aggregated chemokine
Smart peptide synthesis: Synthesis of the Rantes
Synthesis of neurotoxic prion peptide (106 - 126)
Smart peptide synthesis: Synthesis of PADRE-Muc chimeric peptide
Synthesis of highly amyloidogenic human IAPP using pseudoproline dipeptides
Expediting convergent synthesis with pseudoproline dipeptides
Synthesis of long peptides using pseudoproline dipeptides
Stepwise solid phase synthesis of a 120 residue peptide related to FAS death domain
Expediting the Fmoc solid phase synthesis of long peptides through the application of dimethyloxazolidine dipeptides
Guidelines for the use of pseudoproline dipeptides
Synthesis design using pseudoproline dipeptides
Exploring strategies for peptide synthesis
Overcoming side-reactions
Application of Dmb-Dipeptides in the Fmoc SPPS of Difficult and Aspartimide-Prone Sequences
New derivatives for overcoming aspartimide formation
Overcoming aspartimide in Fmoc SPPS

© Merck KGaA, Darmstadt, Germany, 2012


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